Abstract: We report on discrete element method simulations of a pseudo-two-dimensional (pseudo-2D) fluidized bed to investigate particle–wall interactions. Detailed information on macroscopic flow field variables, including solids pressure, granular temperature, and normal and tangential wall stresses are analyzed. The normal wall stress differs from the solids pressure because of the strong anisotropic flow behavior in the pseudo-2D system. A simple linear relationship exists between normal wall stress and solids pressure. In addition, an effective friction coefficient can be derived to characterize particle–wall flow interaction after evaluating the normal and tangential wall stresses. The effects of inter-particle and particle–wall friction coefficients are evaluated. Strong anisotropic flow behavior in the pseudo-2D system needs to be considered to validate the two-fluid model where the boundary condition is usually developed based on an isotropic assumption. The conclusion has been confirmed by simulation with different particle stiffnesses. Assumptions in the newly developed model for 2D simulation are further examined against the discrete element method simulation.