Abstract: An artificial neural network (ANN) method is introduced to predict drop size in two kinds of pulsed columns with small-scale data sets. After training, the deviation between calculate and experimental results are 3.8% and 9.3%, respectively. Through ANN model, the influence of interfacial tension and pulsation intensity on the droplet diameter has been developed. Droplet size gradually increases with the increase of interfacial tension, and decreases with the increase of pulse intensity. It can be seen that the accuracy of ANN model in predicting droplet size outside the training set range is reach the same level as the accuracy of correlation obtained based on experiments within this range. For two kinds of columns, the drop size prediction deviations of ANN model are 9.6% and 18.5% and the deviations in correlations are 11% and 15%.