Abstract: To ensure the usefulness of simulation technologies in practice, their credibility needs to be established with Uncertainty Quantification (UQ) methods. In this project smart proxy is introduced to significantly reduce the computational cost of conducting large number of multiphase CFD simulations. Smart proxy for CFD models are developed using pattern recognition capabilities of Artificial Intelligence (AI), Machine Learning (LM) and Data Mining (DM) technologies. Several CFD simulation runs with different inlet air velocities for a rectangular fluidized bed are used to create a smart CFD proxy that is capable of replicating the CFD results for a wide variety of inlet velocities. The smart CFD proxy is validated with blind CFD runs (CFD runs that have not played any role during the development [training, calibration and validation] of the smart CFD proxy). In our earlier work, CFD data was used to train ANN at the cell level. That is an ANN was trained for each computational cell used in the CFD simulations. In the present work, the ANN is constructed and trained based on cross sectional area average of each variable, such as pressure, velocities and volume fraction (Layer Level). This leads to improvements in the training time at the expense of less spatial resolution. The resulting trained ANN provides spatially average value of parameters of interest, along the length of the fluidized bed. Upon completion of this project, UQ studies that rely on hundreds or thousands of smart CFD proxy runs can be accomplished in minutes. Following figure demonstrates a validation example (blind CFD run) showing the results from the MFiX and the smart CFD proxy for pressure drop across a fluidized bed at time-step of 1400 (the layer number corresponds to the vertical location in the bed).